N-acetylglucosamine 2-Epimerase from Pedobacter heparinus: First Experimental Evidence of a Deprotonation/Reprotonation Mechanism

N-acetylglucosamine 2-Epimerase from Pedobacter heparinus: First Experimental Evidence of a Deprotonation/Reprotonation Mechanism

The control of cellular N-acetylmannosamine (ManNAc) levels has been postulated to be an effective way to modulate the decoration of cell surfaces with sialic acid. N-acetylglucosamine 2-epimerase catalyzes the interconversion of N-acetylglucosamine (GlcNAc) and ManNAc. Herein, we describe the cloni...

Full description

Bibliographic Details
Main Authors: Su-Yan Wang, Pedro Laborda, Ai-Min Lu, Xu-Chu Duan, Hong-Yu Ma, Li Liu, Josef Voglmeir
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Catalysts
Subjects:
sialic acid metabolism
N-acetylglucosamine 2-epimerase
deprotonation/reprotonation mechanism
Neu5Ac analogues
synthesis of sialic acid analogues
Online Access:http://www.mdpi.com/2073-4344/6/12/212

Internet

http://www.mdpi.com/2073-4344/6/12/212

Similar Items