Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate

Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate

Caspase-2 is an evolutionarily conserved but enigmatic protease whose biological role remains poorly understood. To date, research into the functions of caspase-2 has been hampered by an absence of reagents that can distinguish its activity from that of the downstream apoptotic caspase, caspase-3....

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Bibliographic Details
Main Authors: Tanja Kitevska, Sarah J. Roberts, Delara Pantaki‑Eimany, Sarah E. Boyd, Fiona L. Scott, Christine J. Hawkins
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-03-01
Series:Bioscience Reports
Subjects:
apoptosis
caspase
cleavage
protease
Runx1
substrate
Online Access:http://www.bioscirep.org/bsr/034/e100/bsr034e100.htm

Internet

http://www.bioscirep.org/bsr/034/e100/bsr034e100.htm

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