Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional heterogeneity of adipose stromal cells has remained unresolved. We combined single-cell RNA-sequencing and FACS to identify and isolate functi...

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Bibliographic Details
Main Authors: Chelsea Hepler, Bo Shan, Qianbin Zhang, Gervaise H Henry, Mengle Shao, Lavanya Vishvanath, Alexandra L Ghaben, Angela B Mobley, Douglas Strand, Gary C Hon, Rana K Gupta
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
adipogenesis
obesity
adipose tissue
mural cells
fibrosis
inflammation
Online Access:https://elifesciences.org/articles/39636

Internet

https://elifesciences.org/articles/39636

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