Rifampicin does not significantly affect the expression of Small heterodimer partner (SHP) in primary human hepatocytes

Rifampicin does not significantly affect the expression of Small heterodimer partner (SHP) in primary human hepatocytes

The small/short heterodimer partner (SHP, NR0B2) is a nuclear receptor corepressor lacking a DNA binding domain. SHP is induced by bile acid-activated farnesoid X receptor (FXR) resulting in CYP7A1 gene suppression. In contrast, Pregnane X receptor (PXR) activation by its ligands was recently sugges...

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Bibliographic Details
Main Authors: Petr ePavek, Lucie eStejskalova, Lucie eKrausova, Michal eBitman, Radim eVrzal, Zdenek eDvorak
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Pharmacology
Subjects:
cytochrome P450
CYP3A4
induction
PXR
SHP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00001/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00001/full

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