Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed <i>β</i>H-Crystallins Polymerization in Calcium-Induced Experimental Cataract

Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed <i>β</i>H-Crystallins Polymerization in Calcium-Induced Experimental Cataract

In an in vitro Ca<sup>2+</sup>-induced cataract model, the progression of opacification is paralleled by a rapid decrease of the endogenous levels of spermidine (SPD) and an increase of transglutaminase type 2 (TG2, EC 2.3.2.13)-catalyzed lens crystallins cross-linking by protein-bound &...

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Bibliographic Details
Main Authors: Carlo Mischiati, Giordana Feriotto, Claudio Tabolacci, Fabio Domenici, Sonia Melino, Ilaria Borromeo, Cinzia Forni, Angelo De Martino, Simone Beninati
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
rabbit eye lens
cataract
TG2
spermidine
FAD-PAO
protein post-translation modification
Online Access:https://www.mdpi.com/1422-0067/21/15/5427

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https://www.mdpi.com/1422-0067/21/15/5427

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