SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization

Summary: Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor prognosis. In this study, we use isogenic cancer c...

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Bibliographic Details
Main Authors: Chao Dai, Jonathan P. Rennhack, Taylor E. Arnoff, Maneesha Thaker, Scott T. Younger, John G. Doench, August Yue Huang, Annan Yang, Andrew J. Aguirre, Belinda Wang, Evan Mun, Joyce T. O’Connell, Ying Huang, Katherine Labella, Jessica A. Talamas, Ji Li, Nina Ilic, Justin Hwang, Andrew L. Hong, Andrew O. Giacomelli, Ole Gjoerup, David E. Root, William C. Hahn
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
PDAC
metastasis
colonization
FOSL1
SMAD4
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721008603

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http://www.sciencedirect.com/science/article/pii/S2211124721008603

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