Low-dose LBH589 increases the sensitivity of cisplatin to cisplatin-resistant ovarian cancer cells

Low-dose LBH589 increases the sensitivity of cisplatin to cisplatin-resistant ovarian cancer cells

Objective: There is a need to develop alternative therapeutic strategies to overcome cisplatin-associated resistance in patients with ovarian cancer. Histone deacetylation (HDAC) associated with inactivation of genes has been implicated in the epigenetic silencing of tumor suppressor genes affecting...

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Bibliographic Details
Main Authors: Yen-Ying Ma, Hao Lin, Jau-Sung Moh, Kuang-Den Chen, I-Wen Wang, Yu-Che Ou, Ying-Shu You, Chia-Chi Lung
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Taiwanese Journal of Obstetrics & Gynecology
Subjects:
Cisplatin
Drug resistance
LBH589
Ovarian cancer
Sensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S1028455911000416

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http://www.sciencedirect.com/science/article/pii/S1028455911000416

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