Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates

Rhee, Pokrovskaya et al. utilize 3D electron microscopy of mouse jugular vein puncture wounds to reveal thrombi structured around localized, nucleated platelet aggregates that produced a vaulted thrombus capped by extravascular platelet adherence. As a result, the authors propose a “Cap and Build” p...

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Main Authors:	Sung W. Rhee, Irina D. Pokrovskaya, Kelly K. Ball, Kenny Ling, Yajnesh Vedanaparti, Joshua Cohen, Denzel R. D. Cruz, Oliver S. Zhao, Maria A. Aronova, Guofeng Zhang, Jeffrey A. Kamykowski, Richard D. Leapman, Brian Storrie
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02615-y

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spelling	doaj-576b9d87891e479cb420267b55d5590f2021-09-19T11:15:03ZengNature Publishing GroupCommunications Biology2399-36422021-09-014111310.1038/s42003-021-02615-yVenous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregatesSung W. Rhee0Irina D. Pokrovskaya1Kelly K. Ball2Kenny Ling3Yajnesh Vedanaparti4Joshua Cohen5Denzel R. D. Cruz6Oliver S. Zhao7Maria A. Aronova8Guofeng Zhang9Jeffrey A. Kamykowski10Richard D. Leapman11Brian Storrie12Department of Pharmacology and Toxicology, University of Arkansas for Medical SciencesDepartment of Physiology and Cell Biology, University of Arkansas for Medical SciencesDepartment of Pharmacology and Toxicology, University of Arkansas for Medical SciencesLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthDepartment of Physiology and Cell Biology, University of Arkansas for Medical SciencesLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthDepartment of Physiology and Cell Biology, University of Arkansas for Medical SciencesRhee, Pokrovskaya et al. utilize 3D electron microscopy of mouse jugular vein puncture wounds to reveal thrombi structured around localized, nucleated platelet aggregates that produced a vaulted thrombus capped by extravascular platelet adherence. As a result, the authors propose a “Cap and Build” paradigm of primary hemostasis.https://doi.org/10.1038/s42003-021-02615-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sung W. Rhee Irina D. Pokrovskaya Kelly K. Ball Kenny Ling Yajnesh Vedanaparti Joshua Cohen Denzel R. D. Cruz Oliver S. Zhao Maria A. Aronova Guofeng Zhang Jeffrey A. Kamykowski Richard D. Leapman Brian Storrie
spellingShingle	Sung W. Rhee Irina D. Pokrovskaya Kelly K. Ball Kenny Ling Yajnesh Vedanaparti Joshua Cohen Denzel R. D. Cruz Oliver S. Zhao Maria A. Aronova Guofeng Zhang Jeffrey A. Kamykowski Richard D. Leapman Brian Storrie Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates Communications Biology
author_facet	Sung W. Rhee Irina D. Pokrovskaya Kelly K. Ball Kenny Ling Yajnesh Vedanaparti Joshua Cohen Denzel R. D. Cruz Oliver S. Zhao Maria A. Aronova Guofeng Zhang Jeffrey A. Kamykowski Richard D. Leapman Brian Storrie
author_sort	Sung W. Rhee
title	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_short	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_full	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_fullStr	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_full_unstemmed	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_sort	venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-09-01
description	Rhee, Pokrovskaya et al. utilize 3D electron microscopy of mouse jugular vein puncture wounds to reveal thrombi structured around localized, nucleated platelet aggregates that produced a vaulted thrombus capped by extravascular platelet adherence. As a result, the authors propose a “Cap and Build” paradigm of primary hemostasis.
url	https://doi.org/10.1038/s42003-021-02615-y
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Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates

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