From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae.

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae.

Given the rise in drug-resistant Streptococcus pneumoniae, there is an urgent need to discover new antimicrobials targeting this pathogen and an equally urgent need to characterize new drug targets. A promising antibiotic target is dihydrodipicolinate synthase (DHDPS), which catalyzes the rate-limit...

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Bibliographic Details
Main Authors: Con Dogovski, Michael A Gorman, Natalia E Ketaren, Judy Praszkier, Leanne M Zammit, Haydyn D Mertens, Gary Bryant, Ji Yang, Michael D W Griffin, F Grant Pearce, Juliet A Gerrard, Geoffrey B Jameson, Michael W Parker, Roy M Robins-Browne, Matthew A Perugini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3862839?pdf=render

Internet

http://europepmc.org/articles/PMC3862839?pdf=render

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