Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer’s disease (AD) agents. The rationale of this study was the conjugation of a benzylpiperidine/benzylpiperazine moiety with derivatives of bioactiv...

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Bibliographic Details
Main Authors: Luca Piemontese, Daniel Tomás, Asha Hiremathad, Vito Capriati, Emanuel Candeias, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Alzheimer’s disease
multipotent drugs
donepezil mimetics
AChE inhibitors
anti-Aβ aggregation
Online Access:http://dx.doi.org/10.1080/14756366.2018.1491564

Internet

http://dx.doi.org/10.1080/14756366.2018.1491564

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