Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis.

Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis.

The desmosome anchors keratin filaments in epithelial cells leading to the formation of a tissue wide IF network. Loss of the desmosomal plaque protein plakophilin3 (PKP3) in HCT116 cells, leads to an increase in neoplastic progression and metastasis, which was accompanied by an increase in K8 level...

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Bibliographic Details
Main Authors: Nileema Khapare, Samrat T Kundu, Lalit Sehgal, Mugdha Sawant, Rashmi Priya, Prajakta Gosavi, Neha Gupta, Hunain Alam, Madhura Karkhanis, Nishigandha Naik, Milind M Vaidya, Sorab N Dalal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3368841?pdf=render

Internet

http://europepmc.org/articles/PMC3368841?pdf=render

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