Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

Abstract Background α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human familial PD substitution A53T, yet in contras...

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Bibliographic Details
Main Authors: Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein, Kerstin Buck, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, John D. Hulleman, Jagadish Hindupur, Li-Kai Lin, Sonal Padalkar, Lia A. Stanciu, Yuri L. Lyubchenko, Deniz Kirik, Jean-Christophe Rochet
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Molecular Neurodegeneration
Subjects:
Adeno-associated virus
Aggregation
Alpha-synuclein
Amyloid
Fibril
Membrane
Online Access:http://link.springer.com/article/10.1186/s13024-020-00380-w

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http://link.springer.com/article/10.1186/s13024-020-00380-w

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