Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives

Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives

Abstract Post-translational methylation of histone lysine or arginine residues plays important roles in gene regulation and other physiological processes. Aberrant histone methylation caused by a gene mutation, translocation, or overexpression can often lead to initiation of a disease such as cancer...

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Bibliographic Details
Main Authors: Yongcheng Song, Fangrui Wu, Jingyu Wu
Format: Article
Language:English
Published: BMC 2016-06-01
Series:Journal of Hematology & Oncology
Subjects:
Histone methylation
Enzyme inhibitor
Histone lysine methyltransferase
Protein arginine methyltransferase
Histone demethylase
Cancer therapeutics
Online Access:http://link.springer.com/article/10.1186/s13045-016-0279-9

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http://link.springer.com/article/10.1186/s13045-016-0279-9

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