Protective and Therapeutic Effects of an IL-15:IL-15Rα-Secreting Cell-Based Cancer Vaccine Using a Baculovirus System

Protective and Therapeutic Effects of an IL-15:IL-15Rα-Secreting Cell-Based Cancer Vaccine Using a Baculovirus System

This study reports the use of the BacMam system to deliver and express self-assembling IL-15 and IL-15Rα genes to murine B16F10 melanoma and CT26 colon cancer cells. BacMam-based IL-15 and IL-15Rα were well-expressed and assembled to form the biologically functional IL-15:IL-15Rα complex. Immunizati...

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Bibliographic Details
Main Authors: Van Anh Do-Thi, Hayyoung Lee, Hye Jin Jeong, Jie-Oh Lee, Young Sang Kim
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
interleukin 15
interleukin 15Rα
B16F10 melanoma
CT-26
cytokine
anticancer
Online Access:https://www.mdpi.com/2072-6694/13/16/4039

Internet

https://www.mdpi.com/2072-6694/13/16/4039

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