Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways

Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways

Endogenous glucocorticoids (GCs) are steroid hormones that signal in virtually all cell types to modulate tissue homeostasis throughout life. Also, synthetic GC derivatives (pharmacological GCs) constitute the first-line treatment in many chronic inflammatory conditions with unquestionable therapeut...

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Bibliographic Details
Main Authors: Lisa M. Sevilla, Alba Jiménez-Panizo, Andrea Alegre-Martí, Eva Estébanez-Perpiñá, Carme Caelles, Paloma Pérez
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
glucocorticoids
glucocorticoid receptor
resistance/sensitivity
mitogen-activated protein kinases (MAPKs)
dual-specific phosphatases (DUSPs)
chronic inflammation
Online Access:https://www.mdpi.com/1422-0067/22/18/10049

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https://www.mdpi.com/1422-0067/22/18/10049

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