Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis.

Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis.

Sirtuin 1 (Sirt1) is a class III histone deacetylase (HDAC) that modulates gene expression and is involved in the regulation of proinflammatory cytokines. Interleukin-23 (IL-23) is produced by activated macrophages and dendritic cells and could fuel the progression of rheumatoid arthritis (RA). The...

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Bibliographic Details
Main Authors: Daniel Wendling, Wasim Abbas, Marie Godfrin-Valnet, Amit Kumar, Xavier Guillot, Kashif Aziz Khan, Claire Vidon, Laurie Coquard, Eric Toussirot, Clément Prati, Georges Herbein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370395?pdf=render

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http://europepmc.org/articles/PMC4370395?pdf=render

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