Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires

Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires

Human leukocyte antigen (HLA)-DR15 is a haplotype associated with multiple sclerosis. It contains the two DRB* genes DRB1*1501 (DR2b) and DRB5*0101 (DR2a). The reported anchor motif of the corresponding HLA-DR molecules was determined in 1994 based on a small number of peptide ligands and binding as...

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Bibliographic Details
Main Authors: Erika Margaret Scholz, Miguel Marcilla, Xavier Daura, David Arribas-Layton, Eddie A. James, Iñaki Alvarez
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
human leukocyte antigen-DR
binding motif
mass spectrometry
peptidome
multiple sclerosis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00984/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00984/full

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