Fatty Acid Conjugation Leads to Length-Dependent Antimicrobial Activity of a Synthetic Antibacterial Peptide (Pep19-4LF)

Fatty Acid Conjugation Leads to Length-Dependent Antimicrobial Activity of a Synthetic Antibacterial Peptide (Pep19-4LF)

The increasing number of infections caused by multidrug-resistant bacteria requires an intensified search for new antibiotics. Pep19-4LF is a synthetic antimicrobial peptide (GKKYRRFRWKFKGKLFLFG) that was previously designed with the main focus on high antimicrobial activity. The hydrophobic motif,...

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Bibliographic Details
Main Authors: Philip Storck, Florian Umstätter, Sabrina Wohlfart, Cornelius Domhan, Christian Kleist, Julia Werner, Klaus Brandenburg, Stefan Zimmermann, Uwe Haberkorn, Walter Mier, Philipp Uhl
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antibiotics
Subjects:
synthetic antimicrobial peptides
fatty acid conjugation
antimicrobial activity
<i>Staphylococcus aureus</i>
<i>Enterococcus faecium</i>
Online Access:https://www.mdpi.com/2079-6382/9/12/844

Internet

https://www.mdpi.com/2079-6382/9/12/844

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