Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies

Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies

Misfolding, aggregation and deposition of α-synuclein (α-syn) are major pathologic characteristics of Parkinson’s disease (PD) and the related synucleinopathy, multiple system atrophy (MSA). The spread of α-syn pathology across brain regions is thought to play a key role in the onset and progression...

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Bibliographic Details
Main Authors: Tritia R. Yamasaki, Kenjiro Ono, Lap Ho, Giulio M. Pasinetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein
aggregation
microbiome
polyphenol
Parkinson’s disease
multiple system atrophy
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00398/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00398/full

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