SUMO targets the APC/C to regulate transition from metaphase to anaphase

Signal transduction by small ubiquitin-like modifier (SUMO) is important for cell cycle progression. Here the authors show that SUMOylation regulates the APC/C complex, a master orchestrator of metaphase to anaphase transition, with consequences for mitotic progression.

Bibliographic Details
Main Authors:	Karolin Eifler, Sabine A. G. Cuijpers, Edwin Willemstein, Jonne A. Raaijmakers, Dris El Atmioui, Huib Ovaa, René H. Medema, Alfred C. O. Vertegaal
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03486-4

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spelling	doaj-5797f95b8c1741f1b90f2f7c055ba7792021-05-11T09:32:23ZengNature Publishing GroupNature Communications2041-17232018-03-019111510.1038/s41467-018-03486-4SUMO targets the APC/C to regulate transition from metaphase to anaphaseKarolin Eifler0Sabine A. G. Cuijpers1Edwin Willemstein2Jonne A. Raaijmakers3Dris El Atmioui4Huib Ovaa5René H. Medema6Alfred C. O. Vertegaal7Department of Molecular Cell Biology, Leiden University Medical CenterDepartment of Molecular Cell Biology, Leiden University Medical CenterDepartment of Molecular Cell Biology, Leiden University Medical CenterOncode Institute and Division of Cell Biology, The Netherlands Cancer InstituteOncode Institute and Department of Chemical Immunology, Leiden University Medical CenterOncode Institute and Department of Chemical Immunology, Leiden University Medical CenterOncode Institute and Division of Cell Biology, The Netherlands Cancer InstituteDepartment of Molecular Cell Biology, Leiden University Medical CenterSignal transduction by small ubiquitin-like modifier (SUMO) is important for cell cycle progression. Here the authors show that SUMOylation regulates the APC/C complex, a master orchestrator of metaphase to anaphase transition, with consequences for mitotic progression.https://doi.org/10.1038/s41467-018-03486-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Karolin Eifler Sabine A. G. Cuijpers Edwin Willemstein Jonne A. Raaijmakers Dris El Atmioui Huib Ovaa René H. Medema Alfred C. O. Vertegaal
spellingShingle	Karolin Eifler Sabine A. G. Cuijpers Edwin Willemstein Jonne A. Raaijmakers Dris El Atmioui Huib Ovaa René H. Medema Alfred C. O. Vertegaal SUMO targets the APC/C to regulate transition from metaphase to anaphase Nature Communications
author_facet	Karolin Eifler Sabine A. G. Cuijpers Edwin Willemstein Jonne A. Raaijmakers Dris El Atmioui Huib Ovaa René H. Medema Alfred C. O. Vertegaal
author_sort	Karolin Eifler
title	SUMO targets the APC/C to regulate transition from metaphase to anaphase
title_short	SUMO targets the APC/C to regulate transition from metaphase to anaphase
title_full	SUMO targets the APC/C to regulate transition from metaphase to anaphase
title_fullStr	SUMO targets the APC/C to regulate transition from metaphase to anaphase
title_full_unstemmed	SUMO targets the APC/C to regulate transition from metaphase to anaphase
title_sort	sumo targets the apc/c to regulate transition from metaphase to anaphase
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	Signal transduction by small ubiquitin-like modifier (SUMO) is important for cell cycle progression. Here the authors show that SUMOylation regulates the APC/C complex, a master orchestrator of metaphase to anaphase transition, with consequences for mitotic progression.
url	https://doi.org/10.1038/s41467-018-03486-4
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SUMO targets the APC/C to regulate transition from metaphase to anaphase

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