Novel functions of FoxM1: from molecular mechanisms to cancer therapy

by Mónica eAlvarez-Fernández, René H Medema
Published 2013-03-01

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

by Daniël O. Warmerdam, Jeroen van den Berg, René H. Medema
Published 2016-03-01

Balanced Activity of Three Mitotic Motors Is Required for Bipolar Spindle Assembly and Chromosome Segregation

by Roy G.H.P. van Heesbeen, Marvin E. Tanenbaum, René H. Medema
Published 2014-08-01

Combined Inactivation of Pocket Proteins and APC/C^Cdh1 by Cdk4/6 Controls Recovery from DNA Damage in G1 Phase

by Indra A. Shaltiel, Alba Llopis, Melinda Aprelia, Rob Klompmaker, Apostolos Menegakis, Lenno Krenning, René H. Medema
Published 2021-03-01

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

by Mar Soto, Jonne A. Raaijmakers, Bjorn Bakker, Diana C.J. Spierings, Peter M. Lansdorp, Floris Foijer, René H. Medema
Published 2017-06-01

Hypersensitivity to DNA damage in antephase as a safeguard for genome stability

by Femke M. Feringa, Lenno Krenning, André Koch, Jeroen van den Berg, Bram van den Broek, Kees Jalink, René H. Medema
Published 2016-08-01

Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells

by Iraia García-Santisteban, Alba Llopis, Lenno Krenning, Jon Vallejo-Rodríguez, Bram van den Broek, Ana M. Zubiaga, René H. Medema
Published 2021-02-01

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes.

by Nannette Jelluma, Arjan B Brenkman, Ian McLeod, John R Yates, Don W Cleveland, René H Medema, Geert J P L Kops
Published 2008-01-01

SUMO targets the APC/C to regulate transition from metaphase to anaphase

by Karolin Eifler, Sabine A. G. Cuijpers, Edwin Willemstein, Jonne A. Raaijmakers, Dris El Atmioui, Huib Ovaa, René H. Medema, Alfred C. O. Vertegaal
Published 2018-03-01

Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence

by Apostolos Menegakis, Rob Klompmaker, Claire Vennin, Aina Arbusà, Maartje Damen, Bram van den Broek, Daniel Zips, Jacco van Rheenen, Lenno Krenning, René H. Medema
Published 2021-03-01

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised

by Jonne A. Raaijmakers, Roy G.H.P. van Heesbeen, Vincent A. Blomen, Louise M.E. Janssen, Ferdy van Diemen, Thijn R. Brummelkamp, René H. Medema
Published 2018-02-01

Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.

by Renske van Leuken, Linda Clijsters, Wouter van Zon, Dan Lim, XueBiao Yao, Rob M F Wolthuis, Michael B Yaffe, René H Medema, Marcel A T M van Vugt
Published 2009-01-01

Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.

by Daniël Splinter, Marvin E Tanenbaum, Arne Lindqvist, Dick Jaarsma, Annette Flotho, Ka Lou Yu, Ilya Grigoriev, Dieuwke Engelsma, Elize D Haasdijk, Nanda Keijzer, Jeroen Demmers, Maarten Fornerod, Frauke Melchior, Casper C Hoogenraad, René H Medema, Anna Akhmanova
Published 2010-04-01

Degree and site of chromosomal instability define its oncogenic potential

by Wilma H. M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H. M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J. P. L. Kops, Nannette Jelluma
Published 2020-03-01

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity

by Luiza S. E. P. Will Castro, Luiza S. E. P. Will Castro, Wietske Pieters, Mir Farshid Alemdehy, Muhammad A. Aslam, Muhammad A. Aslam, Olimpia Alessandra Buoninfante, Jonne A. Raaijmakers, Bas Pilzecker, Paul C. M. van den Berk, Hein te Riele, René H. Medema, Rozangela C. Pedrosa, Heinz Jacobs
Published 2021-02-01

Mutations in LRRC50 predispose zebrafish and humans to seminomas.

by Sander G Basten, Erica E Davis, Ad J M Gillis, Ellen van Rooijen, Hans Stoop, Nikolina Babala, Ive Logister, Zachary G Heath, Trudy N Jonges, Nicholas Katsanis, Emile E Voest, Freek J van Eeden, Rene H Medema, René F Ketting, Stefan Schulte-Merker, Leendert H J Looijenga, Rachel H Giles
Published 2013-04-01