Preclinical validations of [18F]FPyPEGCBT-c(RGDfK): a 18F-labelled RGD peptide prepared by ligation of 2-cyanobenzothiazole and 1,2-aminothiol to image angiogenesis

Preclinical validations of [18F]FPyPEGCBT-c(RGDfK): a 18F-labelled RGD peptide prepared by ligation of 2-cyanobenzothiazole and 1,2-aminothiol to image angiogenesis

Abstract Background αVβ3, αVβ5 and α5β1 integrins are known to be involved in carcinogenesis and are overexpressed in many types of tumours compared to healthy tissues; thereby they have been selected as promising therapeutic targets. Positron emission tomography (PET) is providing a unique non-inva...

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Bibliographic Details
Main Authors: Didier J. Colin, James A. H. Inkster, Stéphane Germain, Yann Seimbille
Format: Article
Language:English
Published: SpringerOpen 2016-10-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Angiogenesis
Integrins
RGD peptide
Fluorine-18
MicroPET imaging
Online Access:http://link.springer.com/article/10.1186/s41181-016-0019-z

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http://link.springer.com/article/10.1186/s41181-016-0019-z

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