Genetic variation in the 3'-UTR of CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2 and UGT2B7: potential effect on regulation by microRNA and pharmacogenomics relevance

Genetic variation in the 3'-UTR of CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2 and UGT2B7: potential effect on regulation by microRNA and pharmacogenomics relevance

Introduction: Pharmacogenomics research has concentrated on variation in genes coding for drug metabolising enzymes, transporters and nuclear receptors. However, variation affecting microRNA could also play a role in drug response. This project set out to investigate potential microRNA target sites...

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Bibliographic Details
Main Authors: Marelize eSwart, Collet eDandara
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Genetics
Subjects:
microRNA
pharmacogenomics
polymorphisms
Bioinformatics prediction
drug metabolising enzymes
mirSNPs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00167/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00167/full

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