Inhibition of both EGFR and IGF1R sensitized prostate cancer cells to radiation by synergistic suppression of DNA homologous recombination repair.

Inhibition of both EGFR and IGF1R sensitized prostate cancer cells to radiation by synergistic suppression of DNA homologous recombination repair.

Reduced sensitivity of prostate cancer (PC) cells to radiation therapy poses a significant challenge in the clinic. Activation of epidermal growth factor receptor (EGFR), type 1 insulin-like growth factor receptor (IGF1R), and crosstalk between these two signaling pathways have been implicated in th...

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Bibliographic Details
Main Authors: Yong Wang, Jian Lin Yuan, Yun Tao Zhang, Jian Jun Ma, Peng Xu, Chang Hong Shi, Wei Zhang, Yu Mei Li, Qiang Fu, Guang Feng Zhu, Wei Xue, Yong Hua Lei, Jing Yu Gao, Juan Ying Wang, Chen Shao, Cheng Gang Yi, He Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3741308?pdf=render

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http://europepmc.org/articles/PMC3741308?pdf=render

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