Partial Replacement of Nucleosomal DNA with Human FACT Induces Dynamic Exposure and Acetylation of Histone H3 N-Terminal Tails

Partial Replacement of Nucleosomal DNA with Human FACT Induces Dynamic Exposure and Acetylation of Histone H3 N-Terminal Tails

Summary: The FACT (facilitates chromatin transcription) complex, comprising SPT16 and SSRP1, conducts structural alterations during nucleosome unwrapping. Our previous cryoelectron microscopic (cryo-EM) analysis revealed the first intermediate structure of an unwrapped nucleosome with human FACT, in...

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Bibliographic Details
Main Authors: Yasuo Tsunaka, Hideaki Ohtomo, Kosuke Morikawa, Yoshifumi Nishimura
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Biochemistry
Molecular Biology
Structural Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308336

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http://www.sciencedirect.com/science/article/pii/S2589004220308336

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