Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

Microglia, the brain’s resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we report an unprecedented level of microglial depletion and establish a model system that achieves an emp...

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Bibliographic Details
Main Authors: Lindsay A Hohsfield, Allison R Najafi, Yasamine Ghorbanian, Neelakshi Soni, Joshua Crapser, Dario X Figueroa Velez, Shan Jiang, Sarah E Royer, Sung Jin Kim, Caden M Henningfield, Aileen Anderson, Sunil P Gandhi, Ali Mortazavi, Matthew A Inlay, Kim N Green
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
microglia
depletion
CSF1R
repopulation
white matter
Online Access:https://elifesciences.org/articles/66738

Internet

https://elifesciences.org/articles/66738

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