Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema.

Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema.

The adaptor protein p66Shc regulates intracellular oxidant levels through the modulation of a forkhead-related transcription factor (FOXO3a). The genetic ablation of p66Shc (p66Shc-/-) renders mice resistant to oxidative stress and p53-dependent apoptosis. We investigated whether p66Shc ablation in...

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Bibliographic Details
Main Authors: Benedetta Lunghi, Giovanna De Cunto, Eleonora Cavarra, Silvia Fineschi, Barbara Bartalesi, Giuseppe Lungarella, Monica Lucattelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0119797

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https://doi.org/10.1371/journal.pone.0119797

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