Study on the cellular internalization mechanisms and in vivo anti-bone metastasis prostate cancer efficiency of the peptide T7-modified polypeptide nanoparticles

Study on the cellular internalization mechanisms and in vivo anti-bone metastasis prostate cancer efficiency of the peptide T7-modified polypeptide nanoparticles

Bone-metastasis prostate cancer (BMPCa)-targeting gene therapy is gaining increasing concern in recent years. The peptide T7-modified polypeptide nanoparticles for delivery DNA (CRD-PEG-T7/pPMEPA1) was prepared as our previous study. However, the feasibility of CRD-PEG-T7/pPMEPA1 for BMPCa treatment...

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Bibliographic Details
Main Authors: Yongwei Gu, Xinmei Chen, Haiyan Zhang, Heyi Wang, Hang Chen, Sifan Huang, Youfa Xu, Yuansheng Zhang, Xin Wu, Jianming Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
gene therapy
bone-metastases prostate cancer
cellular internalization mechanisms
anti-tumor effect
administration safety
Online Access:http://dx.doi.org/10.1080/10717544.2019.1709923

Internet

http://dx.doi.org/10.1080/10717544.2019.1709923

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