ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis

ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis

Coordination of cell-cell adhesion, actomyosin dynamics and gene expression is crucial for morphogenetic processes underlying tissue and organ development. Rho GTPases are main regulators of the cytoskeleton and adhesion. They are activated by guanine nucleotide exchange factors in a spatially and t...

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Bibliographic Details
Main Authors: Robert Beal, Ana Alonso-Carriazo Fernandez, Dimitris K. Grammatopoulos, Karl Matter, Maria S. Balda
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ARHGEF18
AKAP12
trophoblasts
cell-cell adhesion
RhoA
CREB
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.658006/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.658006/full

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