Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice

Well-ordered soluble HIV-1 envelope glycoprotein (Env) spike mimetics such as Native Flexibly Linked (NFL) trimers display high homogeneity, desired antigenicity, and high in vitro stability compared to previous generation soluble HIV-1 Env trimers. Glutaraldehyde (GLA) cross-linking was shown to fu...

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Bibliographic Details
Main Authors: Martina Soldemo, Monika Àdori, Julian M. Stark, Yu Feng, Karen Tran, Richard Wilson, Lifei Yang, Javier Guenaga, Richard T. Wyatt, Gunilla B. Karlsson Hedestam
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
HIV-1 env
gluteraldehyde
cross-linking
immunogenicity
mice
vaccine responses
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01654/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01654/full

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