Optimal regulation of blood glucose level in Type I diabetes using insulin and glucagon.

The Glucose-Insulin-Glucagon nonlinear model accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes. Based on this model, we design infusion rates of either insulin (monotherapy) or insulin and glucagon (dual therapy) that can...

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Bibliographic Details
Main Authors: Afroza Shirin, Fabio Della Rossa, Isaac Klickstein, John Russell, Francesco Sorrentino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213665