Large-Scale Gene Expression Signatures Reveal a Microbicidal Pattern of Activation in Mycobacterium leprae-Infected Monocyte-Derived Macrophages With Low Multiplicity of Infection

Large-Scale Gene Expression Signatures Reveal a Microbicidal Pattern of Activation in Mycobacterium leprae-Infected Monocyte-Derived Macrophages With Low Multiplicity of Infection

Leprosy is a disease with a clinical spectrum of presentations that is also manifested in diverse histological features. At one pole, lepromatous lesions (L-pole) have phagocytic foamy macrophages heavily parasitized with freely multiplying intracellular Mycobacterium leprae. At the other pole, the...

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Bibliographic Details
Main Authors: Thyago Leal-Calvo, Bruna Leticia Martins, Daniele Ferreira Bertoluci, Patricia Sammarco Rosa, Rodrigo Mendes de Camargo, Giovanna Vale Germano, Vania Nieto Brito de Souza, Ana Carla Pereira Latini, Milton Ozório Moraes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
macrophages
Mycobacterium leprae
eQTLs
SNPs
host-directed therapy
leprosy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.647832/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.647832/full

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