LET-Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of miRNAs that Drive Inhibition

LET-Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of miRNAs that Drive Inhibition

Summary: Space radiation inhibits angiogenesis by two mechanisms depending on the linear energy transfer (LET). Using human 3D micro-vessel models, blockage of the early motile stage of angiogenesis was determined to occur after exposure to low LET ions (<3 KeV/AMU), whereas inhibition of the lat...

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Bibliographic Details
Main Authors: Yen-Ruh Wuu, Burong Hu, Hazeem Okunola, Amber M. Paul, Elizabeth A. Blaber, Margareth Cheng-Campbell, Afshin Beheshti, Peter Grabham
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Radiation Biology
Molecular Biology
Space Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309688

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http://www.sciencedirect.com/science/article/pii/S2589004220309688

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