G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalization.

G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalization.

G beta 5 (Gbeta5, Gβ5) is a unique G protein β subunit that is thought to be expressed as an obligate heterodimer with R7 regulator of G protein signaling (RGS) proteins instead of with G gamma (Gγ) subunits. We found that D2-dopamine receptor (D2R) coexpression enhances the expression of Gβ5, but n...

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Bibliographic Details
Main Authors: J Christopher Octeau, Joseph M Schrader, Ikuo Masuho, Meenakshi Sharma, Christopher Aiudi, Ching-Kang Chen, Abraham Kovoor, Jeremy Celver
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4146516?pdf=render

Internet

http://europepmc.org/articles/PMC4146516?pdf=render

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