Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of <i>Smo</i> in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss

Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of <i>Smo</i> in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss

The functional role of the Hedgehog (Hh)-signaling pathway has been widely investigated in bone physiology/development. Previous studies have, however, focused primarily on <i>Hh</i> functions in bone formation, while its roles in bone resorption have not been fully elucidated. Here, we...

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Bibliographic Details
Main Authors: Yukihiro Kohara, Ryuma Haraguchi, Riko Kitazawa, Yuuki Imai, Sohei Kitazawa
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
osteoclasts
Hedgehog signaling
cyclopamine
GANT-58
GANT-61
Smoothened
Online Access:https://www.mdpi.com/1422-0067/21/8/2745

Internet

https://www.mdpi.com/1422-0067/21/8/2745

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