TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals

TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals

Adoptive T cell therapy (ACT) is a rapidly evolving therapeutic approach designed to harness T cell specificity and function to fight diseases. Based on the evidence that T lymphocytes can mediate a potent anti-tumor response, initially ACT solely relied on the isolation, in vitro expansion, and inf...

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Bibliographic Details
Main Authors: Francesco Manfredi, Beatrice Claudia Cianciotti, Alessia Potenza, Elena Tassi, Maddalena Noviello, Andrea Biondi, Fabio Ciceri, Chiara Bonini, Eliana Ruggiero
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
TCR - T cell receptor
genetic engineering
cancer immunotherapy
adoptive T cell immunotherapy
cancer immunoediting
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01689/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01689/full

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