The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure

The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure

Abstract Aims Excessive activation of Ca/calmodulin‐dependent kinase II (CaMKII) is of critical importance in heart failure (HF) and atrial fibrillation. Unfortunately, lack of selectivity, specificity, and bioavailability have slowed down development of inhibitors for clinical use. We investigated...

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Bibliographic Details
Main Authors: Julian Mustroph, Marzena Drzymalski, Maria Baier, Steffen Pabel, Alexander Biedermann, Bernadette Memmel, Melanie Durczok, Stefan Neef, Can Martin Sag, Bernhard Floerchinger, Leopold Rupprecht, Christof Schmid, York Zausig, Guillaume Bégis, Veronique Briand, Marie‐Laure Ozoux, Dorothee Tamarelle, Veronique Ballet, Philip Janiak, Philippe Beauverger, Lars S. Maier, Stefan Wagner
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:ESC Heart Failure
Subjects:
Inhibition
Heart failure
Contractility
SR Ca leak
Arrhythmias
Online Access:https://doi.org/10.1002/ehf2.12895

Internet

https://doi.org/10.1002/ehf2.12895

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