Peroxisome proliferator-activated receptor α controls cellular cholesterol trafficking in macrophages

Peroxisome proliferator-activated receptor α controls cellular cholesterol trafficking in macrophages

The mobilization of cholesterol from intracellular pools to the plasma membrane is a determinant that governs its availability for efflux to extracellular acceptors. NPC1 and NPC2 are proteins localized in the late endosome and control cholesterol transport from the lysosome to the plasma membrane....

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Bibliographic Details
Main Authors: G. Chinetti-Gbaguidi, E. Rigamonti, L. Helin, A.L. Mutka, M. Lepore, J.C. Fruchart, V. Clavey, E. Ikonen, S. Lestavel, B. Staels
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Journal of Lipid Research
Subjects:
nuclear receptors
gene regulation
atherosclerosis
cholesterol homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520328601

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http://www.sciencedirect.com/science/article/pii/S0022227520328601

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