Non-genomic Actions of Methylprednisolone Differentially Influence GABA and Glutamate Release From Isolated Nerve Terminals of the Rat Hippocampus

Non-genomic Actions of Methylprednisolone Differentially Influence GABA and Glutamate Release From Isolated Nerve Terminals of the Rat Hippocampus

Corticosteroids exert a dual role in eukaryotic cells through their action via (1) intracellular receptors (slow genomic responses), or (2) membrane-bound receptors (fast non-genomic responses). Highly vulnerable regions of the brain, like the hippocampus, express high amounts of corticosteroid rece...

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Bibliographic Details
Main Authors: Rafael Neiva, Ana Caulino-Rocha, Fátima Ferreirinha, Maria Graça Lobo, Paulo Correia-de-Sá
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
methylprednisolone
glucocorticoid receptors
mineralocorticoid receptors
synchronous GABA and glutamate release
hippocampal nerve terminals
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00146/full

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https://www.frontiersin.org/article/10.3389/fnmol.2020.00146/full

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