Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo

Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo

FK506 (Tacrolimus) is a potent inhibitor of calcineurin that blocks IL2 production and is widely used to prevent transplant rejection and treat autoimmunity. FK506 treatment of dendritic cells (FKDC) limits their capacity to stimulate T cell responses. FK506 does not prevent DC survival, maturation,...

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Bibliographic Details
Main Authors: Dana E Orange, Nathalie E Blachere, John Fak, Salina Parveen, Mayu O Frank, Margo Herre, Suyan Tian, Sebastien Monette, Robert B Darnell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-02-01
Series:eLife
Subjects:
dendritic cell
rheumatoid arthritis
autoimmunity
drug delivery
FK506
Online Access:https://elifesciences.org/articles/00105

Internet

https://elifesciences.org/articles/00105

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