New strategies with anti-IgE in allergic diseases
IgE has long been known as a therapeutic target for allergic disease, but the difficulty has been in selecting agents that don't trigger cross linkage of IgE when bound to its high affinity receptor (FceR1) on mast cells and basophils. By “designing” a monoclonal antibody (mAb) which targets th...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | World Allergy Organization Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455119302479 |