Evolutionarily conserved bias of amino-acid usage refines the definition of PDZ-binding motif

<p>Abstract</p> <p>Background</p> <p>The interactions between PDZ (PSD-95, Dlg, ZO-1) domains and PDZ-binding motifs play central roles in signal transductions within cells. Proteins with PDZ domains bind to PDZ-binding motifs almost exclusively when the motifs are loca...

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Bibliographic Details
Main Authors: Launey Thomas, Chimura Takahiko, Ito Masao
Format: Article
Language:English
Published: BMC 2011-06-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/12/300