Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

Objective: In individuals with mitochondrial disease, respiratory viral infection can result in metabolic decompensation with mitochondrial hepatopathy. Here, we used a mouse model of liver-specific Complex IV deficiency to study hepatic allostasis during respiratory viral infection. Methods: Mice w...

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Bibliographic Details
Main Authors: Maxim Jestin, Senta M. Kapnick, Tatyana N. Tarasenko, Cassidy T. Burke, Patricia M. Zerfas, Francisca Diaz, Hilary Vernon, Larry N. Singh, Ronald J. Sokol, Peter J. McGuire
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Molecular Metabolism
Subjects:
Immunometabolism
Mitochondrial disease
Influenza
Viral infection
Kupffer cells
TNFα
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300557

Internet

http://www.sciencedirect.com/science/article/pii/S2212877820300557

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