Examining the Role of Metabolites in Bioequivalence Assessment

PURPOSE. Investigate the role of metabolites in bioequivalence (BE) assessment. METHODS. Sets of ordinary differential equations are used to generate concentration - time data for both parent drug (P) and metabolite (M). The calculations include 24 subjects, two different formulations (Test, Refer...

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Bibliographic Details
Main Authors: Vangelis Karalis, Panos Macheras
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2010-06-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/7766