Encounter complexes and dimensionality reduction in protein–protein association

Encounter complexes and dimensionality reduction in protein–protein association

An outstanding challenge has been to understand the mechanism whereby proteins associate. We report here the results of exhaustively sampling the conformational space in protein–protein association using a physics-based energy function. The agreement between experimental intermolecular paramagnetic...

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Bibliographic Details
Main Authors: Dima Kozakov, Keyong Li, David R Hall, Dmitri Beglov, Jiefu Zheng, Pirooz Vakili, Ora Schueler-Furman, Ioannis Ch Paschalidis, G Marius Clore, Sandor Vajda
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
encounter landscapes
FFT sampling
protein-protein interaction
Online Access:https://elifesciences.org/articles/01370

Internet

https://elifesciences.org/articles/01370

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