Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis

Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis

The Leishmania parasite resides and replicates within host macrophages during visceral leishmaniasis (VL). This study aimed to evaluate neopterin, a marker of macrophage activation, as possible pharmacodynamic biomarker to monitor VL treatment response and to predict long-term clinical relapse of VL...

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Bibliographic Details
Main Authors: Anke E. Kip, Monique Wasunna, Fabiana Alves, Jan H. M. Schellens, Jos H. Beijnen, Ahmed M. Musa, Eltahir A. G. Khalil, Thomas P. C. Dorlo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
neopterin
biomarker
visceral leishmaniasis
kala-azar
macrophage activation
pharmacodynamics
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00181/full

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00181/full

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