Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo

Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo

Dysregulation of the fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling pathway is frequently observed in multiple human malignancies, and thus, therapeutic strategies targeting FGFs and FGFRs in human cancer are being extensively explored. We observed the activation o...

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Bibliographic Details
Main Authors: Sergei Boichuk, Aigul Galembikova, Pavel Dunaev, Ekaterina Micheeva, Elena Valeeva, Maria Novikova, Natalya Khromova, Pavel Kopnin
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
gastrointestinal stromal tumor cells (GIST)
imatinib (IM)
resistance
FGFR signaling
Online Access:http://www.mdpi.com/1420-3049/23/10/2643

Internet

http://www.mdpi.com/1420-3049/23/10/2643

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