Interface matters: the stiffness route to stability of a thermophilic tetrameric malate dehydrogenase.

In this work we investigate by computational means the behavior of two orthologous bacterial proteins, a mesophilic and a thermophilic tetrameric malate dehydrogenase (MalDH), at different temperatures. Namely, we quantify how protein mechanical rigidity at different length- and time-scales correlat...

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Bibliographic Details
Main Authors: Maria Kalimeri, Eric Girard, Dominique Madern, Fabio Sterpone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4250060?pdf=render