Interface matters: the stiffness route to stability of a thermophilic tetrameric malate dehydrogenase.
In this work we investigate by computational means the behavior of two orthologous bacterial proteins, a mesophilic and a thermophilic tetrameric malate dehydrogenase (MalDH), at different temperatures. Namely, we quantify how protein mechanical rigidity at different length- and time-scales correlat...
Main Authors: | Maria Kalimeri, Eric Girard, Dominique Madern, Fabio Sterpone |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4250060?pdf=render |
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