miR-219-5p inhibits receptor tyrosine kinase pathway by targeting EGFR in glioblastoma.

miR-219-5p inhibits receptor tyrosine kinase pathway by targeting EGFR in glioblastoma.

Glioblastoma is one of the common types of primary brain tumors with a median survival of 12-15 months. The receptor tyrosine kinase (RTK) pathway is known to be deregulated in 88% of the patients with glioblastoma. 45% of GBM patients show amplifications and activating mutations in EGFR gene leadin...

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Bibliographic Details
Main Authors: Soumya Alige Mahabala Rao, Arivazhagan Arimappamagan, Paritosh Pandey, Vani Santosh, Alangar Sathyaranjandas Hegde, Bangalore Ashwathnarayanara Chandramouli, Kumaravel Somasundaram
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3656853?pdf=render

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http://europepmc.org/articles/PMC3656853?pdf=render

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